A mathematical model for using fuzzy Weibull distribution for the effect of Cisplatin on lung cancer cell
Authors :
K. Radhika 1* , C. Alexander 2 and S. Anbalagan 3
Author Address :
1,3 P.G and Research Department of Mathematics, Rajah Serfoji Government College (Autonomous) [Affiliated to Bharathidasan University, Tiruchirappalli-620024, Tamil Nadu, India.], Thanjavur-613005, Tamil Nadu, India.
2 P.G and Research Department of Mathematics, Raja Doraisingam Government Arts College [Affiliated to Alagappa University, Karaikudi, Tamil Nadu, India.], Sivagangai-630561, Tamil Nadu, India.
Abstract :
The reaction of cisplatin on the cell cycle and DNA synthesis of human lung adenocarcinoma cell line $PC$-9 were analysed by flow cytometry by exposure to cisplatin $(1.0 \mu g/ml)$ for 1 and 24 hours revealed a delayed $S$-phase transit and an gathering of cells in the $G2/M$-Phase.Two type of treatment have been studied with fuzzy failure rate function using fuzzy Weibull distribution.
Keywords :
Failure time, fuzzy weibull distribution, PC-9 cell, cell cycle, DNA synthesis rate.
DOI :
Article Info :
Received : October 12, 2020; Accepted : December 19, 2020.
